MovTub — KinFAST

Adaptive test — questions are selected based on your ability estimate. — Tag: TransportMaximum

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Why is glucose normally absent from urine in healthy individuals, but present in the urine of someone with poorly controlled diabetes mellitus?

Diabetes destroys the proximal convoluted tubule, eliminating glucose reabsorption entirely Glucose is actively secreted into the urine by the distal convoluted tubule in diabetics The glomerulus does not normally filter glucose; in diabetes, glomerular permeability changes and allows glucose into the filtrate In healthy individuals, all filtered glucose is reabsorbed before reaching the urine. In diabetes, the plasma glucose concentration exceeds the transport maximum (Tmax) of the glucose transporters in the proximal tubule, so the excess glucose remains in the filtrate and appears in the urine

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